|
Stomach Neoplasms
|
0.600 |
CausalMutation
|
group |
CLINVAR |
|
|
|
|
Stomach Neoplasms
|
0.600 |
CausalMutation
|
group |
CGI |
|
|
|
|
Stomach Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
|
|
|
|
Lung Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
|
|
|
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
CTD_human |
A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.
|
12374626 |
2002 |
|
Respiratory Syncytial Virus Infections
|
0.210 |
Biomarker
|
group |
BEFREE |
These observations suggest that RSV infection of human respiratory epithelial cells induces the iNOS gene both in vitro and in vivo; this induction may occur rather promptly and involves transcriptional activator IRF-1 induced by the RSV infection itself.
|
10410996 |
1999 |
|
Respiratory Syncytial Virus Infections
|
0.210 |
Biomarker
|
group |
RGD |
[Transcription factors in spinal dorsal root ganglion in rats recurrently infected with respiratory syncytial virus].
|
20045913 |
2009 |
|
Lung diseases
|
0.200 |
Biomarker
|
group |
RGD |
Activation of type II alveolar epithelial cells during acute endotoxemia.
|
11880315 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, this identification of IRF1 as a dual regulator of BV6-induced apoptosis and inflammatory cytokine secretion provides novel insights into determinants of sensitivity towards Smac mimetic and possible implications of Smac mimetic treatment on tumor microenvironment and immune response.
|
25501823 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis.
|
15878912 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
DTX3L and ARTD9 act together as repressors of the tumor suppressor IRF1 in mPCa cells.
|
24886089 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cooperative activity between HER oncogenes and the tumor suppressor IRF-1 results in apoptosis.
|
10391680 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferon regulatory factor 1 (IRF1) shows tumor-suppressor activity by suppressing proliferation of cancer cells.
|
22890831 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The loss of heterozygosity of this gene was found in MDS, which proves that IRF-1 may be a tumor suppressor.
|
10807049 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The putative tumor suppressor interferon regulatory factor-1 is down-regulated in resistant cells, whereas its nucleolar phosphoprotein inhibitor nucleophosmin is up-regulated.
|
12067985 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have shown that IRF-1 in human breast cancer cells results in the down-regulation of survivin, tumor cell death, and the inhibition of tumor growth in vivo in xenogeneic mouse models.
|
26011589 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The exon-skipped form of IRF-1 lacking exons 2 and 3 displayed neither DNA binding nor tumor suppressive activities.
|
7936656 |
1994 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo administration of IRF-1 in a murine model of EA modestly inhibited tumor growth, but did not lead to tumor regression.
|
16533423 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The IRF family consists of six different proteins, of which IRF-1 has been demonstrated to have antiproliferative and tumor suppressive functions.
|
9669677 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IFNgamma is an inflammatory cytokine that induces the expression and function of IFN regulatory factor 1 (IRF1), a tumor suppressor gene that can increase antiestrogen responsiveness.
|
20457620 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In 22% of cases, the tumor was detected only in Smart MAR reconstructed images.
|
31439235 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interferon regulatory factor-1 (IRF-1) is a transcription factor that acts as a tumor suppressor and causes apoptosis in cancer cells.
|
19851330 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although our results are preliminary they suggest that neither the tumor suppressor gene IRF-1 nor the oncogene IRF-2 is involved in the pathogenesis of JMML.
|
10609788 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FFPE sections were macrodissected to enrich for tumor for quantitative assessment of CD274 (PD-L1), PDCD1LG2 (PD-L2), CD8A, and IRF1 by RT-qPCR multiplex mRNA panel.
|
31533832 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To monitor cell proliferation in vivo, 1.5 × 10(6) cells carrying the S/MAR minicircle were implanted subcutaneously into mice (n = 5) and as tumors developed significantly more bioluminescence signal was noted at day 35 and 43 compared to day 7 post-implant (p<0.05).
|
24015294 |
2013 |